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Related Experiment Videos

Zero-order release kinetics from a self-correcting floatable asymmetric configuration drug delivery system

L Yang1, R Fassihi

  • 1Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, PA 19140, USA.

Journal of Pharmaceutical Sciences
|February 1, 1996
PubMed
Summary

This study introduces a novel three-layer matrix system for controlled oral drug delivery. The innovative design ensures zero-order drug release over 16 hours without an initial burst effect.

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Controlled drug release systems are crucial for improving therapeutic efficacy and patient compliance.
  • Oral drug delivery remains the most preferred route, necessitating advanced formulation strategies.

Purpose of the Study:

  • To develop and evaluate a novel three-layer matrix system for controlled oral drug release.
  • To investigate the drug release kinetics and influencing factors of the developed system.

Main Methods:

  • Utilizing three-layer matrix technology with polyethylene oxide polymers and theophylline as a model drug.
  • Direct compression of the formulation into an asymmetric floatable system with distinct layer properties.
  • Conducting a 16-hour dissolution study to assess drug release profiles.

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Main Results:

  • The system demonstrated complete drug release over 16 hours, following zero-order kinetics.
  • No burst release effect was observed, with a consistent release rate of approximately 0.1 mg/min.
  • Drug release kinetics were independent of pH and compression force, but sensitive to layer thickness and formulation.

Conclusions:

  • The three-layer matrix technology offers a viable approach for achieving controlled oral drug delivery.
  • The release mechanism is governed by a balance between polymer front advancement and erosion.
  • This formulation strategy holds promise for developing effective sustained-release oral dosage forms.