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The immune adherence phenomenon in experimental candidiasis
Zentralblatt Fur Bakteriologie, Parasitenkunde, Infektionskrankheiten Und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie Und Parasitologie
|April 1, 1977
Summary
The immune adherence reaction was observed in experimental candidiasis for the first time. This immune response to Candida albicans antibodies strengthens over time and with increased inoculations.
Area of Science:
- Immunology
- Mycology
- Infectious Diseases
Background:
- The immune adherence reaction is a known immunological phenomenon.
- Its presence in experimental candidiasis has not been previously documented.
Purpose of the Study:
- To investigate the immune adherence reaction in experimental candidiasis.
- To detect anti-Candida albicans antibodies using this reaction.
Main Methods:
- Forty-eight guinea pig sera were analyzed post-Candida albicans inoculation.
- The immune adherence reaction was assessed at various time points.
- Agglutination and indirect mast cell degranulation tests were used for parallel comparison.
Main Results:
- A positive immune adherence reaction was detected from day 14 post-inoculation.
- The reaction's titer and strength increased with time and number of inoculations.
- Results were compared with agglutination and degranulation tests.
Conclusions:
- The immune adherence reaction is a viable method for detecting antibodies in experimental candidiasis.
- This reaction shows a time- and dose-dependent increase in response to Candida albicans.