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Human cytomegalovirus is not implicated in benign prostatic hyperplasia: a study using immunohistochemistry and the
A M Stapleton1, R H Williams, T L Timme
1Matsunaga-Conte Prostate Cancer Research Center, Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030, USA.
Purpose:
To evaluate whether human cytomegalovirus (CMV) may play a role in the pathogenesis of benign prostatic hyperplasia.
Materials And Methods:
We used immunohistochemistry and the polymerase chain reaction (PCR) to evaluate the presence of CMV in normal prostatic tissue (n = 12) and BPH tissue (n = 21).
Results:
Immunostaining for CMV in prostatic tissue was negative; however, staining was evident in mononuclear cells seen in the tissues of both groups. With nested PCR, CMV genomic material was demonstrated in 1 tissue specimen from each group (p > 0.1).
Conclusions:
These data suggest that CMV is unlikely to be a significant factor in the pathogenesis of BPH.