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Related Experiment Videos

Sibling reflux: a dual center retrospective study

J Wan1, S P Greenfield, M Ng

  • 1Children's Hospital of Buffalo, State University of New York at Buffalo, USA.

The Journal of Urology
|August 1, 1996
PubMed
Summary
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Screening all siblings for vesicoureteral reflux (VUR) is recommended, even older children. While VUR incidence decreases with age, reflux nephropathy is still found in older siblings.

Area of Science:

  • Pediatric Nephrology
  • Urology

Background:

  • Siblings of children with vesicoureteral reflux (VUR) have a higher incidence of the condition.
  • Previous studies may have selection bias due to higher screening rates in female siblings.
  • The necessity of screening older children for VUR is debated.

Purpose of the Study:

  • To determine the incidence of VUR in siblings of index patients.
  • To assess the prevalence of reflux nephropathy in siblings.
  • To evaluate the impact of age on VUR and reflux nephropathy incidence in siblings.

Main Methods:

  • Retrospective review of 422 families with 622 siblings of VUR probands.
  • Evaluation of siblings aged newborn to 16 years.
  • Analysis of VUR incidence and reflux nephropathy based on age and sex.

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Main Results:

  • Vesicoureteral reflux (VUR) was identified in 27% of siblings (144/622), with a higher rate in girls (33%).
  • The majority of VUR cases were low grade (II-III).
  • Reflux nephropathy was found in 13.6% of tested siblings, with 27% of these being over 10 years old.

Conclusions:

  • Universal screening of siblings for VUR is advised.
  • Despite a decreased incidence after age 7, older siblings can still develop reflux nephropathy.
  • Screening older siblings is crucial as they represent a significant proportion of those with reflux nephropathy.