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[Evaluation of left ventricular diastolic function using gated SPECT with 99mTc-MIBI]

M Toba1, S I Kumita, S Mizumura

  • 1Department of Radiology, Nippon Medical School, Japan.

Kaku Igaku. the Japanese Journal of Nuclear Medicine
|April 1, 1996
PubMed
Summary

New parameters from technetium-99m-labeled sestamibi (99mTc-MIBI) gated SPECT show promise for evaluating left ventricular diastolic function in patients with ischemic heart disease.

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Area of Science:

  • Nuclear Medicine
  • Cardiology
  • Medical Imaging

Background:

  • Gated single-photon emission computed tomography (SPECT) systems, particularly those using technetium-99m (99mTc)-labeled radiopharmaceuticals, are established for assessing left ventricular systolic function.
  • Left ventricular diastolic function assessment often requires separate or more complex imaging techniques.

Purpose of the Study:

  • To evaluate the feasibility of assessing left ventricular diastolic function using routine 99mTc-MIBI gated SPECT data.
  • To identify novel parameters from 99mTc-MIBI gated SPECT that correlate with established diastolic function indices.

Main Methods:

  • Twenty-nine patients with ischemic heart disease underwent 99mTc-MIBI gated SPECT and 99mTc-human serum albumin diethylene triamine pentaacetic acid (99mTc-HSAD) ventriculography.

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  • Regions of interest were placed on myocardial images from gated SPECT data to generate phase count curves.
  • New parameters, including 1/3 Count Decreasing Fraction (1/3 CDF), were calculated and compared with established indices like 1/3 Filling Fraction (1/3 FF) and Peak Filling Rate (PFR).

    • Main Results:

    • Patients were classified into normal, mixed, and delayed relaxation patterns based on their phase count curves, indicating diastolic dysfunction.
    • The phase count curve patterns showed significant differences between normal and abnormal diastolic function groups.
    • The 1/3 CDF parameter demonstrated significant correlations with 1/3 FF (r = 0.61) and PFR (r = 0.58).

    Conclusions:

    • Novel parameters derived from 99mTc-MIBI gated SPECT data, such as 1/3 CDF, appear feasible for evaluating left ventricular diastolic function.
    • This approach may offer a non-invasive method to assess diastolic function within a routine SPECT imaging protocol.
    • Further validation is warranted to establish the clinical utility of these new parameters.