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Sex steroid hormones and macrophage function

L Miller1, J S Hunt

  • 1Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City 66160, USA. lancemil@kuhub.cc.ukans.edu

Life Sciences
|January 1, 1996
PubMed
Summary

Sex steroid hormones like estrogens and androgens significantly impact immune responses by modulating macrophage activation. This review explores how these hormones influence host defense mechanisms involving macrophages.

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Area of Science:

  • Immunology
  • Endocrinology

Background:

  • Macrophages are crucial immune cells with adaptable functions.
  • Environmental signals dictate macrophage activity and effector molecule production.

Purpose of the Study:

  • To review the impact of sex steroid hormones on macrophage activation.
  • To examine the influence of hormones on macrophage effector molecule production.

Main Methods:

  • Literature review of existing studies on sex hormones and macrophages.

Main Results:

  • Sex steroid hormones, including estrogens, progesterone, androgens, and testosterone, influence macrophage activation.
  • These hormones play a significant role in regulating the immune system's response.

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Conclusions:

  • Sex steroid hormones profoundly affect host defense by modulating macrophage participation in immune responses.