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Changes in serum type I and III procollagen levels in children with chronic renal failure
1Department of Pediatric Endocrinology, Medical Faculty, Gazi University, Beşevler Ankara, Turkey.
Insights
Elevated serum aminoterminal propeptide of type III procollagen (PIIINP) in children with chronic renal failure (CRF) may indicate a poor prognosis for kidney disease progression. Further research is needed to understand its impact on growth failure in CRF.
Area of Science:
- Biochemistry
- Pediatrics
- Nephrology
Background:
- Serum levels of carboxyterminal propeptide of type I procollagen (PICP) and aminoterminal propeptide of type III procollagen (PIIINP) are established markers for bone formation.
- These markers are utilized in evaluating pediatric growth disorders.
Purpose of the Study:
- To investigate the prognostic and therapeutic value of PICP and PIIINP in monitoring growth retardation in children with chronic renal failure (CRF).
Main Methods:
- Radioimmunoassay was used to measure serum PICP and PIIINP levels.
- The study included 24 children (4-14 years) with CRF (12 dialysis, 12 non-dialysis) and 12 healthy controls.
Main Results:
- Mean serum PIIINP levels were significantly higher in dialysis patients compared to controls (p < 0.05).
- Pubertal stage did not influence PICP or PIIINP levels.
- No significant correlations were found between PICP and PIIINP, or between these markers and height z-score or bone age.
Conclusions:
- Increased serum PIIINP levels in renal patients may serve as a poor prognostic factor for progressive renal failure and end-stage renal disease.
- Additional research is required to elucidate the role of these collagens in growth failure associated with CRF.
Abstract:
Serum levels of carboxyterminal propeptide of type I procollagen (PICP) and aminoterminal propeptide of type III procollagen (PIIINP) can be used as markers of bone formation and the evaluation of children with growth disorders. We measured the serum levels of these collagens with radioimmunoassay in 24 children aged between 4 and 14 years with chronic renal failure (CRF; n = 12 dialysis, n = 12 nondialysis) and 12 age-matched healthy controls, to find out whether these parameters have a prognostic or therapeutic value in monitoring the growth retardation in CRF. Mean serum PIIINP levels in the dialysis patients were higher than in the control group; the difference between the groups was statistically significant (p < 0.05). It seemed that the pubertal stage of the patients did not affect the levels of PICP and PIIINP. There was no significant correlation between PICP and PIIINP in any patients. Neither PICP nor PIIINP correlated with the height z-score or bone age. It was concluded that the increased serum PIIINP levels in renal patients might be accepted as a poor prognostic factor leading to progressive renal failure and end-stage renal disease. Further investigations into the effects of these collagens on growth failure associated with CRF are needed.