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Related Experiment Videos

Ultrastructure of prolapsed disc

J Sylvest, B Hentzer, T Kobayasi

    Acta Orthopaedica Scandinavica
    |May 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Intervertebral disc prolapse involves changes in chondrocytes and intercellular substances. Ultrastructural analysis reveals cell degeneration and collagen degradation, impacting disc integrity.

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    Rinsho shinkeigaku = Clinical neurology·2000

    Area of Science:

    • Biomedical Science
    • Cell Biology
    • Orthopedics

    Background:

    • Intervertebral disc degeneration is a common cause of back pain.
    • Accurate classification of disc tissue components is crucial for understanding pathology.

    Purpose of the Study:

    • To investigate the ultrastructural changes in prolapsed intervertebral disc tissue.
    • To characterize the cell types and intercellular matrix components in detail.

    Main Methods:

    • Hemilaminectomy was performed to obtain prolapsed disc tissue.
    • Ultrastructural analysis using electron microscopy was conducted on the tissue samples.

    Main Results:

    • The distinction between annulus fibrosus and nucleus pulposus was found to be inaccurate.

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  • Chondrocytes were the predominant cell type, showing normal, cloning, and necrotized forms.
  • Degraded collagen fibrils and glycoprotein material were observed in the intercellular substance.
  • Matrix vesicles, potentially from disintegrated chondrocytes, were present.

    • Conclusions:

    • Disc prolapse involves significant cellular and matrix alterations.
    • Chondrocyte viability and matrix integrity are compromised in prolapsed discs.
    • These ultrastructural findings provide insights into the pathogenesis of disc herniation.