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Serum electrophoretic pattern in osteoarticular tuberculosis

G C Prasad, K Baldev, P K Shukla

    Acta Orthopaedica Scandinavica
    |May 1, 1977
    PubMed
    Summary
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    Serum protein changes in osteoarticular tuberculosis (TB) show decreased albumin and increased Alpha2 and gamma-globulins with disease progression. Treatment reversed these trends, though resistant TB maintained elevated gamma-globulins.

    Area of Science:

    • Biochemistry
    • Immunology
    • Infectious Diseases

    Background:

    • Osteoarticular tuberculosis is a significant global health challenge.
    • Serum protein electrophoresis is a valuable diagnostic tool.
    • Understanding protein profile alterations in tuberculosis is crucial for patient management.

    Purpose of the Study:

    • To investigate serum protein electrophoretic patterns in osteoarticular tuberculosis.
    • To correlate these patterns with disease severity, chronicity, and treatment response.
    • To analyze patterns in streptomycin-resistant cases.

    Main Methods:

    • Serum electrophoresis was performed on 37 patients with established osteoarticular tuberculosis.
    • Data were analyzed based on disease severity, chronicity, and post-treatment status.

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  • Streptomycin-resistant cases were specifically included.

    • Main Results:

    • Advanced and chronic osteoarticular tuberculosis showed decreased albumin and increased Alpha2 and gamma-globulin fractions.
    • Antitubercular drug administration led to a reversal of these observed protein changes.
    • Streptomycin-resistant cases exhibited elevated gamma-globulin levels, similar to untreated patients.

    Conclusions:

    • Serum protein electrophoresis can reflect the progression and activity of osteoarticular tuberculosis.
    • Treatment effectively modulates serum protein profiles.
    • Gamma-globulin elevation in resistant cases indicates persistent disease activity.