The effect of propranolol-administration on the electroencephalogram in the rabbit

The effect of propranolol-administration on the electroencephalogram in the rabbit. Acta Physiol. Pol., 1977, 28 (1): 45-50. The influence of propranolol on EEG of the rabbits, with electrodes chronically implanted into different brain structures, was studied. Propranolol in the doses of 1, 2 and 3 mg/kg was injected intravenously. The bioelectrical brain activity of the rabbits was measured several times after the drug injection. In the next period of experiments propranolol (2 mg/kg i.v.) was administered every day for 10 days. Moreover the influence of the same doses of this drug on ECG and arterial pressure was studied. It was found that propranolol-administration changes the bioelectrical activity of the brain. Such phenomenon as, voltage increase, irregular and slower rhythm, an increase in slow activity and spikes, fast activity was perceived. The changes in EEG were particularly well pronounced in subcortical structures. The described effects of propranolol do not depend on the influence of this drug on the circulatory system.