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Metanephric adenoma: histology, immunophenotype, cytogenetics, ultrastructure
Z Gatalica1, S Grujic, A Kovatich
1Department of Pathology and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Summary
Metanephric adenoma is a rare kidney tumor with unique features. Recognizing its distinct characteristics is crucial due to its consistently benign clinical course.
Area of Science:
- Nephrology
- Oncology
- Pathology
Background:
- Metanephric adenoma is a rare renal neoplasm.
- It presents unique histological and clinical characteristics.
Observation:
- A case of metanephric adenoma was identified in a 54-year-old woman.
- The tumor was large, well-circumscribed, solid, and tan, resembling developing metanephric tubular epithelium.
- Histologically, it comprised uniformly small epithelial cells arranged in tubules.
Findings:
- Immunohistochemistry revealed expression of the proximal tubule marker URO-2 and wt1 gene protein product.
- Ultrastructural analysis showed epithelial cells with luminal cilia and an abundant basement membrane.
- Cytogenetic analysis confirmed a normal female karyotype.
Implications:
- The distinct histological, immunohistochemical, and ultrastructural features aid in diagnosing metanephric adenoma.
- Clinical and pathological recognition is essential for appropriate management, given its invariably benign nature.