Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pneumonitis-associated hyperprocalcitoninemia

E S Nylén1, R H Snider, K A Thompson

  • 1Veterans Affairs Medical Center, Washington, D.C. 20422, USA.

The American Journal of the Medical Sciences
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Four ppm measurement of the antihydrogen ground-state hyperfine splitting.

Nature·2026
Same author

Be<sup>+</sup> assisted, simultaneous confinement of more than 15000 antihydrogen atoms.

Nature communications·2025
Same author

BOLDistilled: Automated Construction of Comprehensive but Compact DNA Barcode Reference Libraries.

Molecular ecology resources·2025
Same author

NDMA soft-sensors for potable reuse: A model development study.

Water research·2025
Same author

Soil health improvements under cover crops are associated with enhanced soil content of cytokinins.

Plant biology (Stuttgart, Germany)·2024
Same author

Observation of the effect of gravity on the motion of antimatter.

Nature·2023
Same journal

Providers' Perspectives on Hospital-Based Tobacco Treatment Efforts.

The American journal of the medical sciences·2026
Same journal

In Memoriam: Maurice A. Mufson, MD, MACP.

The American journal of the medical sciences·2026
Same journal

Outcomes of Acute Myeloid Leukemia Patients Admitted to the Intensive Care Unit within 100 days of Allogeneic Hematopoietic Stem Cell Transplantation.

The American journal of the medical sciences·2026
Same journal

Association Between Reverse Triiodothyronine and Cardiac Complications in Patients with Uncontrolled Graves' Disease.

The American journal of the medical sciences·2026
Same journal

Chlorthalidone vs. hydrochlorothiazide in hypertension management: Lessons for guiding clinical practice.

The American journal of the medical sciences·2026
Same journal

The impact of COVID-19 on alcohol-associated hepatitis and alcohol-associated cirrhosis.

The American journal of the medical sciences·2026
See all related articles

Elevated procalcitonin (ProCT) levels indicate infectious pneumonitis. Serum ProCT and precursor forms increase rapidly during infection and aspiration, decreasing as pneumonia resolves.

Area of Science:

  • Biochemistry
  • Pulmonology
  • Endocrinology

Background:

  • Procalcitonin (ProCT) is a prohormone of calcitonin (CT).
  • Elevated ProCT is linked to critical illnesses like sepsis and burn injury.
  • The role of ProCT in infectious pneumonitis requires further characterization.

Observation:

  • Patients with acute infectious pneumonia exhibited significantly higher serum total CT levels (1,019 pg/mL) compared to healthy controls (32 pg/mL).
  • Bacterial pneumonia cases showed higher initial ProCT levels (1,793 pg/mL) than non-bacterial cases (242 pg/mL).
  • Serum ProCT levels decreased as pneumonia clinically resolved, with higher levels persisting in patients with incomplete radiographic resolution.

Findings:

  • Serum ProCT levels in infectious pneumonitis patients were substantially elevated, particularly in bacterial infections.

Related Experiment Videos

  • Gel filtration revealed increased precursor CT forms, including ProCT, during acute pneumonitis, which decreased with resolution.
  • Rapid ProCT elevation was observed within 6-12 hours post-aspiration, with precursor forms dominating serum CT.

    • Implications:

    • Circulating ProCT and its precursor forms are sensitive biomarkers for infectious and aspiration pneumonitis.
    • ProCT levels correlate with disease severity and resolution, offering prognostic value.
    • These findings highlight ProCT's potential utility in diagnosing and monitoring lung infections.