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Tissue factor expression during human and mouse development

T Luther1, C Flössel, N Mackman

  • 1Institute of Pathology, Technical University Dresden, Dresden, Germany.

The American Journal of Pathology
|July 1, 1996
PubMed
Summary
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Tissue factor (TF) plays a crucial role in embryonic development, acting as a morphogenic factor. Its expression patterns in mice and humans reveal significant roles in organogenesis and tissue formation during embryogenesis.

Area of Science:

  • Developmental Biology
  • Hemostasis
  • Cell Biology

Background:

  • Tissue factor (TF) is known for its role in hemostasis in adult organisms.
  • Its function during embryonic development (ontogenesis) is largely unknown.

Purpose of the Study:

  • To investigate the significance of TF expression during mammalian development.
  • To compare TF distribution in developing mice and humans.

Main Methods:

  • In situ hybridization and immunohistochemistry were used.
  • TF expression patterns were analyzed in murine and human embryos and fetuses.

Main Results:

  • TF is strongly expressed in ectodermal and entodermal cells during early embryogenesis.
  • Widespread TF expression was observed in epithelial tissues during organogenesis, including epidermis, myocardium, and hepatocytes.

Related Experiment Videos

  • Differences in TF renal expression were noted between humans (glomeruli) and mice (tubular epithelia).
  • Robust TF expression occurred in developing neuroepithelium, skeletal muscle, and pancreas, contrasting with adult expression patterns.
  • Factor VII, the ligand for TF, was not detected in early human embryos.

    • Conclusions:

    • The temporal and spatial expression of TF during development suggests it functions as a key morphogenic factor.
    • TF expression patterns highlight its involvement in embryonic tissue development and organogenesis.