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Acute multiple sclerosis (Marburg type) is associated with developmentally immature myelin basic protein
D D Wood1, J M Bilbao, P O'Connors
1Division of Biochemistry, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
Annals of Neurology
|July 1, 1996
Summary
This study investigated Marburg-type multiple sclerosis (MS), finding immature myelin basic protein (MBP) due to citrullination. This altered MBP may impair its function in compacting nerve fibers.
Area of Science:
- Neuroscience
- Biochemistry
- Pathology
Background:
- Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
- Marburg type MS is an acute, fulminating form with significant neuropathological findings.
- Myelin basic protein (MBP) is a key component of myelin sheath and its alterations are implicated in MS.