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Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
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Desensitization of neurotensin-induced phosphoinositide hydrolysis in transfected CHO cells

E Hermans1, J M Maloteaux

  • 1Laboratoire de Neurochimie, Universite Catholique de Louvain, Brussels, Belgium.

Biochemical Pharmacology
|June 28, 1996
PubMed

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Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...