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Synthesis and alpha,beta-adrenergic blocking potency of 2,3-dihydro-1,4-benzodioxin derivatives. (I)
M Khouili1, G Guillaumet, G Coudert
1Laboratoire de Chimie Bioorganique et Analytique, associé au CNRS, Université d'Orléans, France.
Farmaco (Societa Chimica Italiana : 1989)
|March 1, 1996
Abstract:
The synthesis of a new series of alpha- and beta-adrenergic blocking agents 14 is described. The affinity and selectivity of these compounds for alpha, beta 1 and beta 2-adrenoceptors were studied in comparison with those of WB-4101 and propranolol. The derivatives 14cx and 14dx are more potent beta 1-blockers than propranolol.