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Synthesis and alpha,beta-adrenergic blocking potency of 2,3-dihydro-1,4-benzodioxin derivatives. (II)
M Khouili1, G Guillaumet, G Coudert
1Laboratoire de Chimie Bioorganique et Analytique, associé au CNRS, Université d'Orléans, France.
Farmaco (Societa Chimica Italiana : 1989)
|March 1, 1996
Abstract:
The four stereoisomers of compound 1 were synthesized from 2,3-dihydro-1, 4-benzodioxin and evaluated as alpha- and beta-adrenergic antagonists. Enantiomer 1-b [2R, 2'S] (Figure 1) is the best beta 1-blocking agent. Furthermore all compounds showed a alpha-blocking activity.