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Related Experiment Videos

Recall during intermittent propofol anaesthesia

O Nordström1, R Sandin

  • 1Department of Anaesthesia, Länssjukhuset, Kalmar, Sweden.

British Journal of Anaesthesia
|May 1, 1996
PubMed
Summary

Patients temporarily awakened during propofol anesthesia often have no memory of intraoperative events. This study investigated explicit recall of stimuli presented during these brief wakeful periods in surgical patients.

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Outcome after awareness with explicit recall.

Acta anaesthesiologica Belgica·2007

Area of Science:

  • Anesthesiology
  • Neuroscience
  • Cognitive Psychology

Background:

  • Propofol is a widely used anesthetic agent.
  • Intraoperative awareness can occur during anesthesia.
  • The impact of brief wakefulness on memory during propofol anesthesia is not fully understood.

Purpose of the Study:

  • To assess explicit memory recall in patients briefly awakened during propofol anesthesia.
  • To determine the extent of recall for intraoperative stimuli presented during a temporary discontinuation of propofol infusion.

Main Methods:

  • Twenty patients undergoing incontinence surgery had propofol infusion temporarily discontinued.
  • Patients were tested for recall of stimuli (cough command, digit) presented during the wakeful period.
  • Memory was assessed 1 hour and 24 hours after anesthesia reinstitution.

Main Results:

  • Only 35% of patients recalled any stimuli or being awake.
  • Memory recall was significantly impaired compared to pre-anesthesia learning (P < 0.0001).
  • There were minimal differences in recall between 1-hour and 24-hour testing.

Conclusions:

  • Brief periods of wakefulness during propofol anesthesia may not lead to explicit memory formation.
  • Patients may lack conscious awareness and recall of intraoperative events even when briefly awake.
  • This suggests a potential for undetected intraoperative awareness with impaired memory encoding during propofol infusions.

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