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Conditioned place preference after prolonged pre-exposure to ethanol
P Biénkowski1, P Kuca, W Kostowski
1Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Poland.
Abstract:
Conditioned place preference (CPP) paradigm has been used to test ethanol (EtOH) rewarding properties after repeated (20 days) injections of EtOH. Rats injected with 0.5 g/kg ip of EtOH during pre-exposure period and CPP procedure showed significant place preference to the compartment paired with the drug. Animals receiving higher dose of EtOH (1.0 g/kg) showed no CPP but rather relative aversion to the paired compartment (relatively to saline-treated group). Our result suggests a development of sensitization to EtOH rewarding effect after prolonged administration of low dose of EtOH.