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Related Experiment Videos

Amikacin therapy for gram-negative septicemia

R D Meyer, R P Lewis, S M Finegold

    The American Journal of Medicine
    |June 1, 1977
    PubMed
    Summary

    Amikacin effectively treated gram-negative septicemia, especially in patients resistant to gentamicin. Monitoring amikacin levels is advised to minimize potential kidney and ear toxicity.

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    Area of Science:

    • Infectious Diseases
    • Pharmacology
    • Nephrology

    Background:

    • Gram-negative septicemia poses a significant clinical challenge.
    • Gentamicin resistance in gram-negative pathogens complicates treatment options.

    Purpose of the Study:

    • To evaluate the efficacy and safety of amikacin in patients with gram-negative septicemia.
    • To assess amikacin's utility in cases of gentamicin-resistant infections.

    Main Methods:

    • Amikacin was administered to 18 patients diagnosed with gram-negative septicemia.
    • Patient outcomes, including cure rates and adverse events, were monitored.
    • Serum amikacin levels were assessed in relation to toxicity.

    Main Results:

    • Fourteen out of 18 patients achieved cure with amikacin therapy.
    • Nine of 10 patients with gentamicin-resistant pathogens were successfully treated.
    • Nephrotoxicity and ototoxicity were observed in a subset of patients, associated with elevated serum levels.

    Conclusions:

    • Amikacin is a highly effective treatment for gram-negative bacteremia.
    • It is the preferred agent for infections caused by gentamicin-resistant, amikacin-susceptible gram-negative bacteria.
    • Monitoring serum amikacin levels is crucial for optimizing safety and efficacy.

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