Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polymorphism and smoking in bladder carcinogenesis

F I Chinegwundoh1, A V Kaisary

  • 1Royal Free Hospital Medical School, London, UK.

British Journal of Urology
|May 1, 1996
PubMed
Summary

Smoking is linked to bladder cancer, with heavy smokers developing high-grade tumors. Certain gene variations may influence bladder cancer aggressiveness in smokers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A study of colovesical fistulae in a district hospital.

Annals of the Royal College of Surgeons of England·2009
Same author

Laparoscopic versus open simple prostatectomy: a comparative study.

The Journal of urology·2006
Same author

Evaluating the use of early hormonal therapy in patients with localised or locally advanced prostate cancer.

Prostate cancer and prostatic diseases·2005
Same author

PSA recurrence following radical prostatectomy is comparable for all age groups in the UK.

Prostate cancer and prostatic diseases·2005
Same author

Contemporary update of cancer control after radical prostatectomy in the UK.

British journal of cancer·2004
Same author

Case selection for radical prostatectomy in the UK.

European urology·2004

Area of Science:

  • Oncology
  • Genetics
  • Environmental Health

Background:

  • Smoking is a known risk factor for bladder cancer.
  • Cytochrome P-450 enzymes play a role in metabolizing carcinogens found in tobacco smoke.
  • Genetic variations in these enzymes may influence individual susceptibility to smoking-induced cancers.

Purpose of the Study:

  • To investigate the association between smoking, CYP2D6 gene polymorphism, and bladder cancer development.
  • To explore the relationship between smoking intensity and bladder tumor grade.
  • To determine if CYP2D6 genotype modifies bladder cancer risk or aggressiveness in smokers.

Main Methods:

  • A case-control study involving 126 bladder cancer patients.
  • Detailed smoking history collection.
  • Genomic DNA extraction and CYP2D6 genotyping using polymerase chain reaction (PCR).

Main Results:

  • 78% of bladder cancer patients had a history of smoking.
  • A correlation was observed between smoking quantity ('cigarette-years') and tumor grade; heavy smokers presented with high-grade tumors.
  • A non-statistically significant trend suggested that smokers heterozygous for CYP2D6 developed more aggressive bladder cancer.

Conclusions:

  • The established link between smoking and bladder cancer is reaffirmed.
  • Smoking intensity is directly related to bladder tumor grade.
  • CYP2D6 genotype may play a role in determining bladder cancer type among smokers.

Related Experiment Videos