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Synthesis of Hexahydrocyclopentimidazol-2-(1H)-one derivatives displaying selective DP-receptor agonist properties
P Barraclough1, M L Bolofo, H Giles
1Department of Medicinal Chemistry, Wellcome Research Laboratories, Beckenham, Kent, U.K.
Bioorganic & Medicinal Chemistry
|January 1, 1996
Abstract:
The rationale for investigating conformationally restricted analogues of BW245C as DP-receptor ligands and the syntheses of three such racemic bicyclic imidazolidinone analogues are described. Compounds 7 (BW587C), 8 (BW480C85), and 9 (BW572C85) were found to be potent inhibitors of human platelet aggregation and selective DP-receptor agonists in washed platelet and jugular vein isolated tissue assays.