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Successful treatment of a primary cardiac leiomyosarcoma with ifosfamide and etoposide
P Han1, R A Drachtman, P Amenta
1Department of Pediatrics, Division of Hematology-Oncology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903-0019, USA.
Purpose:
Primary cardiac leiomyosarcoma is a rare malignant tumor in childhood. Patients with unresectable or partially resected cardiac leiomyosarcoma typically have a poor prognosis. The role of chemotherapy in the treatment of these patients has not been well defined.
Patient And Methods:
A 6-week-old infant with an incompletely resected cardiac leiomyosarcoma was treated postoperatively with ifosfamide and etoposide.
Results:
The patient is disease-free and without apparent late effects 5 years following the completion of therapy.
Conclusion:
The combination of ifosfamide and etoposide warrants further evaluation in patients with leiomyosarcoma.