Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Keratins and the skin

E Fuchs1

  • 1Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637, USA.

Annual Review of Cell and Developmental Biology
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Characterization of slow cycling corneal limbal epithelial cells identifies putative stem cell markers.

Scientific reports·2018
Same author

GABA-from Inhibition to Cognition: Emerging Concepts.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2017
Same author

Characterization of slow cycling corneal limbal epithelial cells identifies putative stem cell markers.

Scientific reports·2017
Same author

Transfusion practices for bone marrow harvests: a survey analysis from the AABB Bone Marrow Quality Improvement Initiative Working Group.

Bone marrow transplantation·2017
Same author

Epidermal Snail expression drives skin cancer initiation and progression through enhanced cytoprotection, epidermal stem/progenitor cell expansion and enhanced metastatic potential.

Cell death and differentiation·2013
Same author

Type A-trichothecenes - Quantitative analysis using LC-MS and occurrence in Austrian maize and oats.

Mycotoxin research·2013

Keratin filaments provide essential mechanical strength to skin cells, preventing rupture. Mutations in these structural proteins can lead to blistering skin disorders, highlighting their critical role in epidermal integrity.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Dermatology

Background:

  • Keratins are the primary structural proteins in vertebrate epidermis, forming essential cytoskeletal networks.
  • Keratins are part of the intermediate filament (IF) superfamily, evolving into a multigene family with diverse expression patterns.
  • Vertebrate keratins consist of type I and type II sequences that heterodimerize to form filaments.

Purpose of the Study:

  • To review the expression patterns, structure, and function of skin keratins.
  • To explore the role of keratin filaments in cellular mechanical strength.
  • To postulate new insights into keratin functions and their involvement in human diseases.

Main Methods:

  • Literature review of studies on keratin expression, structure, and function.

Related Experiment Videos

  • Analysis of research on keratin mutations and associated skin disorders.
  • Examination of in vitro and in vivo data regarding keratin filament assembly and cellular mechanics.

    • Main Results:

    • Keratin filaments are crucial for imparting mechanical strength to keratinocytes.
    • Disruptions in keratin filament assembly lead to fragile cells and blistering skin disorders.
    • Keratins play a vital role in maintaining epidermal integrity and cellular resilience.

    Conclusions:

    • Keratin filaments are indispensable for epidermal mechanical stability.
    • Understanding keratin function is key to addressing keratinopathies and related skin diseases.
    • Further research into keratin structure-function relationships may reveal novel therapeutic targets.