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Extra Y chromosome in T-cell acute lymphoblastic leukemia
A Watanabe1, Y Kawachi, T Nishihara
1Department of Internal Medicine, Takamatsu Red Cross Hospital, Kagawa, Japan.
Cancer Genetics and Cytogenetics
|July 1, 1996
Summary
A rare case of T-cell acute lymphoblastic leukemia (ALL) in a 66-year-old man showed an extra Y chromosome as the sole abnormality. This chromosomal change may represent a new finding in T-cell ALL.
Area of Science:
- Hematology
- Cytogenetics
- Oncology
Background:
- T-cell acute lymphoblastic leukemia (ALL) is a serious hematologic malignancy.
- Chromosomal abnormalities are common in ALL and impact prognosis.
- The role of specific chromosomal changes, like extra sex chromosomes, requires further investigation.
Observation:
- A 66-year-old male patient presented with T-cell ALL.
- The leukemic cells exhibited a unique sole clonal chromosomal abnormality: 47,XY,+Y (an extra Y chromosome).
- Immunophenotyping confirmed T-cell lineage, with T-cell receptor genes in germline configuration.
Findings:
- The patient's bone marrow aspirate consistently showed the 47,XY,+Y karyotype in all observed metaphase cells.
- Following chemotherapy, the patient achieved complete remission.
- Post-treatment analysis revealed a normal 46,XY karyotype in bone marrow and peripheral blood lymphocytes.
Implications:
- The extra Y chromosome (47,XY,+Y) is proposed as a potential novel chromosomal abnormality in T-cell ALL.
- This finding may contribute to understanding the diverse genetic landscape of T-cell ALL.
- Further research is warranted to determine the frequency and clinical significance of this abnormality in T-cell ALL.