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Thyroid function and the intraocular pressure response to topical corticosteroids

T Krupin, L S Jacobs, S M Podos

    American Journal of Ophthalmology
    |May 1, 1977
    PubMed
    Summary

    Primary open-angle glaucoma patients do not show altered thyroid function or increased sensitivity to corticosteroids affecting thyroid function. This suggests the pituitary gland

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    Area of Science:

    • Endocrinology
    • Ophthalmology
    • Thyroid Function

    Background:

    • Corticosteroids are used to treat ocular inflammation.
    • Primary open-angle glaucoma (POAG) is a common optic neuropathy.
    • Ocular tissues in POAG patients may exhibit enhanced corticosteroid sensitivity.

    Purpose of the Study:

    • To investigate thyroid function in POAG patients.
    • To determine if POAG is associated with altered thyroid hormone levels.
    • To assess corticosteroid sensitivity of the hypothalamic-pituitary-thyroid axis in POAG.

    Main Methods:

    • Measured baseline thyroxine, TSH, and T3 uptake.
    • Classified patients based on topical intraocular response to corticosteroids.
    • Administered oral dexamethasone to assess TSH suppression.

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    Main Results:

    • Thyroid function and TSH suppression by oral dexamethasone were similar in POAG patients and non-corticosteroid responsive (NN) subjects.
    • POAG was not associated with a higher prevalence of low thyroid function.
    • POAG patients did not show increased glucocorticoid sensitivity related to thyroid function.

    Conclusions:

    • The adenohypophysial thyrotropic cell does not share the enhanced corticosteroid sensitivity seen in ocular tissues, hypothalamus, and lymphocytes of POAG patients.
    • Thyroid function is not directly impacted by the corticosteroid sensitivity characteristic of POAG.
    • Findings suggest a dissociation in corticosteroid sensitivity between ocular/systemic tissues and the pituitary-thyroid axis in POAG.