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Experimental myocarditis in the guinea-pig
1Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences & Technology, India.
Cardiovascular Research
|April 1, 1996
Abstract:
In guinea-pigs, myocarditis was induced under experimental conditions by immunizing the animals with rabbit skeletal muscle myosin-beta. The salient histopathological features were foci of perivascular lymphonononuclear aggregates, necrosis, and degeneration of myocardial cells. Antimyosin-beta antibodies in the immune complexes were demonstrated in the sera of the guinea-pigs. An immune-complex-mediated tissue-injury is proposed in the pathogenesis of myocarditis.

