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Related Experiment Videos

Enalapril-induced toxic pustuloderma

J E Ferguson1, R J Chalmers

  • 1University Department of Dermatology, Salford Royal Hospitals NHS Trust, Lancs, UK.

Clinical and Experimental Dermatology
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

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Enalapril, a common hypertension drug, can rarely cause a severe skin reaction called toxic pustuloderma. This case report highlights a previously undocumented side effect of enalapril therapy.

Area of Science:

  • Pharmacology
  • Dermatology
  • Cardiology

Background:

  • Enalapril is a widely prescribed angiotensin-converting enzyme (ACE) inhibitor used for hypertension and congestive cardiac failure.
  • Skin reactions, including rashes, are uncommon side effects of enalapril, occurring in about 1.4% of patients.
  • A subset of patients (0.4%) may experience a rash severe enough to warrant treatment discontinuation.

Observation:

  • This report details a specific case of toxic pustuloderma, a severe skin condition characterized by pustules.
  • The patient was undergoing enalapril therapy for congestive cardiac failure when the adverse skin reaction developed.
  • The occurrence of toxic pustuloderma in this context is noteworthy.

Findings:

  • A rare and previously unreported case of toxic pustuloderma associated with enalapril therapy is presented.

Related Experiment Videos

  • The adverse skin reaction developed in a patient being treated for congestive cardiac failure.
  • This finding suggests a potential, albeit uncommon, dermatological side effect of enalapril.

    • Implications:

    • This case expands the known spectrum of adverse skin reactions associated with enalapril.
    • Clinicians should be aware of toxic pustuloderma as a potential, rare side effect of enalapril.
    • Further investigation may be warranted to understand the mechanism and incidence of enalapril-induced toxic pustuloderma.