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Updated: Jul 18, 2026
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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Flavanone absorption after naringin, hesperidin, and citrus administration
B Ameer1, R A Weintraub, J V Johnson
1Food Science and Human Nutrition Department, University of Florida, Gainesville.
Clinical Pharmacology and Therapeutics
|July 1, 1996
Summary
Citrus flavonoids like naringin and hesperidin show low bioavailability (<25%) when taken orally. However, related methoxyflavanones are absorbed from grapefruit and orange juices, potentially undergoing glucuronidation before excretion.
Area of Science:
- Nutritional Science
- Pharmacokinetics
- Biochemistry
Background:
- Citrus flavonoids are plant compounds with potential health benefits.
- Understanding their absorption and metabolism is crucial for dietary recommendations.
Purpose of the Study:
- To evaluate the bioavailability and metabolic fate of citrus flavonoids (naringin, hesperidin) and their derivatives.
- To investigate the absorption of flavanones from grapefruit and orange juices.
Main Methods:
- Oral administration of pure naringin and hesperidin.
- Administration of grapefruit and orange juices.
- Analysis of urine and plasma using positive chemical ionization-collisionally activated dissociation tandem mass spectrometry (PCI-CAD MS/MS).
Main Results:
- Low cumulative urinary recovery (<25%) for naringin and hesperidin, indicating poor bioavailability.
- Detection of naringenin and hesperitin aglycones in urine and plasma.
- Identification of absorbed methoxyflavanones from citrus juices, suggesting different absorption pathways.
Conclusions:
- Naringin and hesperidin exhibit low oral bioavailability.
- Citrus juices facilitate the absorption of related methoxyflavanones.
- Absorbed citrus flavanones may be metabolized via glucuronidation prior to excretion.
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