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Mn-DPDP enhanced MR imaging of the liver: analysis of pulse sequence performance
G J Slater1, S Saini, W W Mayo-smith
1Department of Radiology, Massachusetts General Hospital, Boston, USA.
Aim:
To compare liver enhancement and lesion-liver contrast on T1-weighted (T1W) gradient recalled echo (GRE), spin-echo (SE) and fat-suppressed SE (FS-SE) pulse sequences at Manganese-DPDP (Mn-DPDP) enhanced magnetic resonance (MR) imaging of the liver. PATIENTS AND METHODS. Twenty-one patients with known liver lesions were administered 5 mumol/kg of Mn-DPDP. TIW GRE (78/2.3/80 degrees), SE and F-SE (300/12) images were obtained before and 15 min after Mn-DPDP. Signal/noise ratio (SNR) and lesion-liver contrast/noise ratio (CNR) were calculated for each pulse sequence.
Results:
Liver SNR (n = 21) and lesion-liver CNR (n = 10) increased significantly after Mn-DPDP on all three pulse sequences (P < 0.0001). Liver SNR was highest on the FS-SE and GRE pulse sequences (FS-SE = 43.8, GRE = 38.4, SE = 29.2). Lesion-liver CNR was highest on the FS-SE pulse sequence (FS-SE = -29.3, SE = -23.2, GRE = -19.8), which was significantly higher than the GRE pulse sequence (P < 0.05).
Conclusion:
The T1-weighted fat-suppressed SE (FS-SE) pulse sequence provides highest liver enhancement and lesion-liver contrast and is recommended for Mn-DPDP enhanced MR imaging.
Insights
The fat-suppressed spin-echo (FS-SE) pulse sequence offers superior liver enhancement and lesion-to-liver contrast in Manganese-DPDP (Mn-DPDP) enhanced liver MRI. This sequence is recommended for improved diagnostic accuracy in Mn-DPDP enhanced MR imaging.
Area of Science:
- Radiology
- Medical Imaging
- Hepatology
Background:
- Manganese-DPDP (Mn-DPDP) is a contrast agent used in Magnetic Resonance (MR) imaging.
- Optimizing pulse sequences is crucial for maximizing diagnostic information from Mn-DPDP enhanced liver MR imaging.
Purpose of the Study:
- To compare liver enhancement and lesion-to-liver contrast across different T1-weighted (T1W) pulse sequences.
- Evaluate the efficacy of Gradient Recalled Echo (GRE), Spin-Echo (SE), and Fat-Suppressed SE (FS-SE) sequences with Mn-DPDP.
Main Methods:
- Twenty-one patients with liver lesions received Mn-DPDP (5 μmol/kg).
- T1W GRE, SE, and FS-SE images were acquired before and 15 minutes after contrast administration.
- Signal-to-Noise Ratio (SNR) and Contrast-to-Noise Ratio (CNR) were calculated for each sequence.
Main Results:
- All sequences showed significant increases in liver SNR and lesion-liver CNR post-Mn-DPDP (P < 0.0001).
- FS-SE and GRE sequences yielded the highest liver SNR (43.8 and 38.4, respectively).
- FS-SE demonstrated the highest lesion-liver CNR (-29.3), significantly outperforming GRE (P < 0.05).
Conclusions:
- The T1-weighted fat-suppressed spin-echo (FS-SE) sequence provides optimal liver enhancement.
- FS-SE also offers the greatest lesion-to-liver contrast in Mn-DPDP enhanced MR imaging.
- FS-SE is the recommended pulse sequence for Mn-DPDP enhanced liver MR imaging.