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Determination of the absolute configuration of urothion
A Sakurai1, H Horibe, N Kuboyama
1Department of Chemistry, Faculty of Science, Shizuoka University.
Journal of Biochemistry
|September 1, 1995
Abstract:
In order to determine the absolute configuration of urothion (1), the CD spectra of tri-4-chlorobenzoyl derivatives of 2-amino-6-[(3R)-3,4-dihydroxybutyl]pteridin-4(3H)-one and its (3S) compound were compared with that of the tri-4-chlorobenzoyl derivative obtained from the natural product. R-Configuration was concluded for the secondary hydroxyl group on the side chain of 1, which is the same configuration as that of molybdopterin (2). This supports the view that 1 might be a urinary metabolite of 2.