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Dopamine transporters decrease with age

N D Volkow1, Y S Ding, J S Fowler

  • 1Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|April 1, 1996
PubMed
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Healthy aging leads to a decline in dopamine transporters. This study found a 6.6% decrease per decade in striatal dopamine transporters in healthy individuals.

Area of Science:

  • Neuroscience
  • Aging Research
  • Dopaminergic System

Background:

  • Postmortem studies indicate age-related dopamine cell degeneration.
  • Changes in dopamine transporters during healthy aging are not well understood.
  • Dopamine transporter availability is crucial for dopaminergic neurotransmission.

Purpose of the Study:

  • To investigate age-induced changes in dopamine transporter availability in healthy individuals.
  • To quantify the relationship between age and dopamine transporter levels.
  • To assess dopamine transporter changes in subjects without motor impairments.

Main Methods:

  • Positron Emission Tomography (PET) imaging was used.
  • 23 healthy volunteers (aged 20-74) participated.

Related Experiment Videos

  • [11C]d-threo-methylphenidate was the radiotracer used to measure dopamine transporter availability.

    • Main Results:

    • Dopamine transporter availability significantly decreased with age.
    • A strong negative correlation was observed between age and transporter availability in the putamen (r = -0.72) and caudate (r = -0.74).
    • Subjects over 40 years old showed lower transporter availability compared to those under 40.

    Conclusions:

    • Striatal dopamine transporter availability decreases by 6.6% per decade in healthy aging.
    • These findings highlight age-related alterations in the dopaminergic system.
    • The study provides quantitative data on dopamine transporter changes during normal aging.