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[Methodology and clinical usefulness of radioimmunoimaging using radiolabeled monoclonal antibodies]
1Department of Nuclear Medicine, Gunma University School of Medicine.
Radioimmunoimaging is a functional diagnostic radiology mainly using radiolabeled monoclonal antibodies. The radioimmunoimaging may offer the specific targeting of human malignant tumors. Presently available radiolabeled monoclonal antibodies clinically yield an average sensitivity of more than 70% with an average specificity of more than 80% in colorectal and ovarian cancers. The radioimmunoscintigraphy has been demonstrated to be more accurate than methods based on the morphological imaging for the detection of local recurrence in the pelvis. A combination of functional (radioimmunoimaging) and morphological (CT, MRI, etc) images are expected to offer the early detection of recurrent and metastatic diseases.
Radioimmunoimaging is a functional diagnostic radiology mainly using radiolabeled monoclonal antibodies. The radioimmunoimaging may offer the specific targeting of human malignant tumors. Presently available radiolabeled monoclonal antibodies clinically yield an average sensitivity of more than 70% with an average specificity of more than 80% in colorectal and ovarian cancers. The radioimmunoscintigraphy has been demonstrated to be more accurate than methods based on the morphological imaging for the detection of local recurrence in the pelvis. A combination of functional (radioimmunoimaging) and morphological (CT, MRI, etc) images are expected to offer the early detection of recurrent and metastatic diseases.