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Decrease in plasma phenylalanine and tyrosine after phenylalanine-tyrosine free amino acid solutions in man

E A Moja1, V Lucini, F Benedetti

  • 1Chair of Medical Psychology, University of Milan, Padiglione L.I.T.A., Ospedale L. Sacco.

Life Sciences
|May 24, 1996
PubMed
Summary

Ingesting essential amino acids without phenylalanine and tyrosine rapidly lowers plasma levels of these amino acids. This reduction in essential amino acids was linked to a decrease in blood pressure.

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Area of Science:

  • Biochemistry
  • Human Physiology
  • Nutritional Science

Background:

  • Phenylalanine and tyrosine are essential aromatic amino acids crucial for various physiological processes.
  • Dietary intake significantly influences plasma concentrations of these amino acids.
  • Understanding the impact of specific amino acid mixtures on metabolic markers is vital.

Purpose of the Study:

  • To investigate the effect of ingesting a specific essential amino acid mixture lacking phenylalanine and tyrosine on plasma amino acid levels.
  • To determine the relationship between the administered amino acid dose and the resulting changes in plasma phenylalanine and tyrosine.
  • To explore potential associations between altered amino acid levels and cardiovascular parameters.

Main Methods:

  • Five healthy male subjects underwent an overnight fast.

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  • Subjects ingested increasing doses of an amino acid solution containing seven essential amino acids (L-isoleucine, L-leucine, L-lysine, L-methionine, L-threonine, L-tryptophan, L-valine) but lacking phenylalanine and tyrosine.
  • Plasma phenylalanine and tyrosine levels, along with systolic and diastolic arterial pressure, were monitored over time.

    • Main Results:

    • Ingestion of the amino acid solution led to a rapid and dose-proportional decrease in plasma phenylalanine and tyrosine concentrations.
    • At the highest dose (31.5 g), plasma phenylalanine and tyrosine levels dropped to 12.7% and 29.8% of baseline, respectively.
    • These reductions were sustained for at least 6 hours post-ingestion.
    • A concurrent decrease in both systolic and diastolic arterial pressure was observed.

    Conclusions:

    • A specific essential amino acid mixture lacking phenylalanine and tyrosine can effectively reduce plasma levels of these amino acids in healthy individuals.
    • The observed decrease in plasma phenylalanine and tyrosine is dose-dependent and sustained.
    • The reduction in plasma phenylalanine and tyrosine is associated with a decrease in arterial blood pressure, suggesting a potential physiological link.