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Deletion in the 190 kDa antigen gene repeat region of Rickettsia rickettsii
M Matsumoto1, Y Tange, T Okada
1First Department of Internal Medicine, School of Medicine, Ehime University, Japan.
Microbial Pathogenesis
|January 1, 1996
Abstract:
The 190 kDa outer membrane protein of Rickettsia rickettsii is a major immunodominant protective antigen which contains 13 tandem nearly identical repeating sequences. We have identified a deletion in the 190 kDa antigen gene of R. rickettsii strain Smith maintained in the laboratory. The deletion occurred within the repeat region of this gene and the mutated repeat region corresponded to one repeating unit in size.