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[Newly manifested type IIb diabetes presents with significant hyperinsulinemia]
M Wicklmayr1, K Rett, E Standl
1III. Medizinische Abteilung des Schwabinger Krankenhauses und Forschergruppe Diabetes, München.
Medizinische Klinik (Munich, Germany : 1983)
|April 10, 1996
Summary
In new-onset type 2 diabetes, early insulin secretion is reduced, while severe insulin resistance dominates later in the oral glucose tolerance test. This highlights the need for dietary and pharmacological interventions to manage blood glucose.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Diabetes Research
Context:
- Controversy exists regarding insulin status in the early stages of non-insulin-dependent diabetes mellitus (NIDDM).
- Understanding early insulin dynamics is crucial for therapeutic strategies in type 2 diabetes.
Purpose:
- To investigate insulin secretion and action in new-onset type 2 diabetes during an oral glucose tolerance test (oGTT).
- To compare insulin levels between patients with new-onset diabetes and healthy controls.
Summary:
- Ten new-onset type 2 diabetes patients and ten matched controls underwent an oGTT with serum insulin measurements at 0, 30, and 120 minutes.
- Diabetic patients showed elevated basal insulin, similar 30-minute insulin, and significantly higher 120-minute insulin levels compared to controls.
- Results indicate reduced insulin secretion and action at 30 minutes, and predominant insulin resistance at 120 minutes in new-onset diabetes.
Impact:
- Findings underscore the importance of managing postprandial hyperglycemia in new-onset diabetes.
- The study supports therapeutic strategies involving diet and medication to improve insulin resistance and reduce blood glucose levels.