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Chlorophyll and chromosome breakage

D Sarkar1, A Sharma, G Talukder

  • 1Department of Botany, University of Calcutta, India.

Mutation Research
|August 8, 1996
PubMed
Summary

Green vegetables may protect against genotoxicity, but chlorophyll alone is ineffective and can cause chromosome breaks. The protective effect likely comes from other components in the vegetable extract.

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Mutation research·1996

Area of Science:

  • Nutritional Science
  • Genetics
  • Toxicology

Background:

  • Dietary green vegetables are linked to protection against genotoxic agents.
  • Chlorophyll is hypothesized as a key protective compound in green vegetables.
  • Genotoxicity involves mutagenic and clastogenic activities.

Purpose of the Study:

  • To investigate the protective role of Indian spinach extract and chlorophyll against genotoxicity.
  • To determine the clastogenic effects of chlorophyll in vivo.

Main Methods:

  • Oral administration of crude Indian spinach leaf extract and purified chlorophyll to mice.
  • Assessment of genotoxic and clastogenic effects in bone marrow cells.
  • Evaluation of extract toxicity.

Main Results:

  • Crude Indian spinach leaf extract significantly reduced genotoxic effects.
  • Chlorophyll alone, in both crude and purified forms, induced significant chromosome breaks (clastogenicity).
  • The crude leaf extract was non-toxic.

Conclusions:

  • Chlorophyll is not the sole protective factor in green vegetables and can be clastogenic.
  • The protective activity of Indian spinach extract may be due to synergistic interactions among its components, neutralizing chlorophyll's clastogenicity.

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