Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Surveillance imaging in children with primitive neuroectodermal tumors

E Mendel¹, M L Levy, C Raffel

¹Division of Neurological Surgery, Children's Hospital Los Angeles, University of Southern California, USA.

|April 1, 1996

Summary

Routine surveillance imaging for pediatric primitive neuroectodermal tumors (PNETs) can detect recurrences early in asymptomatic children. Early detection via imaging offers a therapeutic window, improving survival compared to symptomatic detection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Arterial stiffness assessment in coronary microvascular dysfunction and heart failure with preserved ejection fraction: An initial report from the WISE-CVD continuation study.

American heart journal plus : cardiology research and practice·2024

Same author

Acceptability, feasibility and cost of point of care testing for sexually transmitted infections among South African adolescents where syndromic management is standard of care.

BMC health services research·2023

Same author

Cold Pressor Testing and Sympathetic Nervous System Contribution to Ischemia with No Obstructive Coronary Artery Disease: Results from the Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction Project.

American heart journal plus : cardiology research and practice·2022

Same author

The First Examination of Diagnostic Performance of Automated Measurement of the Callosal Angle in 1856 Elderly Patients and Volunteers Indicates That 12.4% of Exams Met the Criteria for Possible Normal Pressure Hydrocephalus.

AJNR. American journal of neuroradiology·2021

Same author

Blistering severe cutaneous adverse reactions in children: proposal for paediatric-focused clinical criteria.

The British journal of dermatology·2021

Same author

Consensus, collaboration and care coordination.

The British journal of dermatology·2019

Area of Science:

Pediatric Oncology
Neuro-oncology
Diagnostic Imaging

Background:

Controversy exists regarding the utility of routine surveillance imaging (MRI/CT) for detecting recurrences in children with primitive neuroectodermal tumors (PNETs).
Previous studies suggested limited value, noting that imaging detects few symptomatic recurrences and offers poor survival even when recurrences are identified.

Purpose of the Study:

To evaluate the effectiveness of routine surveillance imaging in detecting tumor recurrence in pediatric patients with PNETs.
To compare survival outcomes between asymptomatic and symptomatic children diagnosed with recurrent PNETs via surveillance imaging.

Main Methods:

Retrospective review of 25 pediatric patients with recurrent PNETs treated between 1985 and 1993.
Analysis of tumor recurrence detection by routine imaging in asymptomatic versus symptomatic patients.

Related Experiment Videos

Comparison of time to recurrence and survival rates based on detection method and symptom status.

Main Results:

Recurrent PNETs were detected by routine imaging in 19 asymptomatic (76%) and 6 symptomatic (24%) patients.
Recurrence was diagnosed significantly earlier in asymptomatic children (15 months mean) compared to symptomatic children (5 months mean).
Asymptomatic patients with recurrences detected via imaging demonstrated prolonged survival compared to symptomatic patients, with survivors living >24 months post-recurrence.

Conclusions:

Early detection of PNET recurrence through surveillance imaging in asymptomatic children provides a critical window for intervention.
Routine surveillance imaging may offer a clinical benefit by enabling timely treatment, potentially improving survival outcomes in pediatric PNET patients.