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[Long-term efficacy of hepatitis B vaccine in children with chronic renal failure]
P Grzesiowski1, H Ziółkowska, B Sobolewska-Wojciechowska
1Katedra i Klinika Pediatrii i Nefrologii Akademii Medycznej w Warszawie.
Insights
Post-vaccination immunity in children with chronic kidney disease is prolonged. A booster dose is recommended if antibody titers fall below 100 mIU/ml to maintain hepatitis B virus (HBV) protection.
Area of Science:
- Pediatric Nephrology
- Immunology
- Vaccinology
Abstract:
The aim of the study was to determine the duration of post vaccination immunity and antibody persistence in children in different stages of chronic renal failure. The study was performed in 25 children and time of observation was 12-36 months. After completing vaccination seroprotection rate was 92% in non-dialysed children and 77% in dialysed. After 36 months of observation seroprotection was found in 90% of patients, none of them was infected by HBV. We conclude that in case of decrease in antibody titer below 100 mIU/ml the booster dose of vaccine is indicated.