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Determination of tablet coating distribution by deconvolution of uncoated and coated tablet weight distributions
1Abbott Laboratories, North Chicago, Illinois 60064-4000, USA.
Purpose:
The purpose of this research is to obtain the tablet coating distribution from weight distributions of uncoated and coated tablets.
Methods:
The method of deconvolution with digital smoothing was used to calculate the distribution of coating applied to a tablet population from separate random measurements of individual uncoated and coated tablets.
Results:
It was demonstrated that the calculated coating weight distribution agrees well with the measured distribution. The effect of the smoothing factor on the solution is illustrated.
Conclusions:
This method can be used during development to facilitate process scale-up/optimization. In routine production, the method can assess the reproducibility and consistency of a coating process.