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Related Experiment Videos

Liver dysfunction in allogeneic bone marrow transplantation recipients

N Azar1, D Valla, I Abdel-Samad

  • 1Département d'Hépato-Gastro-Entérologie, Hôpital Pitié-Salpétrière, Paris, France.

Transplantation
|July 15, 1996
PubMed
Summary
This summary is machine-generated.

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Pre-existing liver lesions are common in bone marrow transplant recipients and contribute to early post-transplant liver dysfunction. These hepatic lesions, similar before and after transplant, highlight the importance of pre-transplant liver health.

Area of Science:

  • Hepatology
  • Hematology
  • Transplantation Medicine

Background:

  • Liver dysfunction is a frequent complication in allogeneic bone marrow transplant recipients.
  • Systematic studies comparing pre- and post-transplantation liver biopsies are lacking.

Purpose of the Study:

  • To investigate the origin of liver disorders before bone marrow transplantation.
  • To determine the mechanism and severity of early post-transplant liver dysfunction.
  • To identify relationships between pre-existing liver lesions and post-transplant liver dysfunction.

Main Methods:

  • Prospective study of 25 bone marrow transplant recipients.
  • Serial viral screening, liver function tests, and pre- and post-transplantation liver biopsies.
  • Histological analysis of liver lesions, including bile duct, central vein, sinusoidal, and portal abnormalities, and parenchymal siderosis.

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Main Results:

  • 72% of patients had abnormal pre-transplant liver tests; 11 had chronic viral hepatitis B or C.
  • All patients showed mild to moderate histological lesions, with high prevalence of portal fibrosis (88%) and parenchymal siderosis (76%).
  • Post-transplant, increased iron overload was the only significant histological difference (96%, P<0.01); fatal veno-occlusive disease occurred in two patients.

Conclusions:

  • Pre-transplant liver lesions are common and contribute to early hepatic dysfunction after bone marrow transplantation.
  • The nature and degree of liver lesions are similar before and after transplantation.
  • Pre-existing hepatic pathology significantly influences outcomes in bone marrow transplant recipients.