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Cytomorphology of leprosy across the Ridley-Jopling spectrum
1Department of Pathology, University College of Medical Sciences, Delhi, India.
Objective:
To evaluate the possible role of cytology in classifying leprosy lesions on the Ridley-Jopling scale.
Study Design:
A double-blind, prospective study comparing cytologic assessment of 30 clinically diagnosed cases of leprosy with their histopathology. May-Grünwald-Giemsa and Ziehl-Neelsen stain were done on slit skin smears and fine needle aspiration material.
Results:
Cytologic subclassification was possible in 23 cases as tuberculoid leprosy (11), midborderline (3), borderline lepromatous (5) and lepromatous leprosy (4). These correlated with histologic subtypes.
Conclusion:
May-Grünwald-Giemsa complements Ziehl-Neelsen stain, yielding information almost comparable to that from histologic examination of skin biopsies.