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Asthma treatment in pregnancy: a randomized controlled study
P J Wendel1, S M Ramin, C Barnett-Hamm
1Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, USA.
American Journal of Obstetrics and Gynecology
|July 1, 1996
Summary
Inhaled corticosteroids significantly reduced asthma readmissions in pregnant women. Intravenous aminophylline provided no therapeutic benefit for asthma exacerbations during pregnancy.
Area of Science:
- Obstetrics and Gynecology
- Pulmonology
- Pharmacology
Background:
- Asthma exacerbations during pregnancy pose risks to both mother and fetus.
- Effective management of asthma exacerbations is crucial for optimal pregnancy outcomes.
Purpose of the Study:
- To evaluate the efficacy of inhaled corticosteroids in managing asthma exacerbations in pregnant women.
- To compare the therapeutic benefits of intravenous aminophylline versus intravenous methylprednisolone for acute asthma exacerbations.
Main Methods:
- A prospective study of 84 pregnant women experiencing 105 asthma exacerbations.
- Randomized assignment to intravenous aminophylline or methylprednisolone for acute exacerbations.
- Post-discharge randomization to inhaled beclomethasone plus oral corticosteroid taper or standard care.
Main Results:
- Intravenous aminophylline did not improve response time or reduce hospital stay.
- Inhaled beclomethasone significantly decreased readmission rates by 55% (12% vs 33%).
- Increased rates of pregnancy-induced hypertension and cesarean delivery were observed.
Conclusions:
- Intravenous aminophylline is not recommended for asthma exacerbations in pregnancy.
- Continuous inhaled corticosteroids are effective in reducing subsequent asthma-related hospital admissions during pregnancy.