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Bone marrow transplantation retinopathy in the absence of radiation therapy
E T Cunningham1, A R Irvine, H S Rugo
1Francis I. Proctor Foundation, University of California Medical Center, San Francisco 94122, USA. emmett@itsa.ucsf.edu
Purpose:
To describe a case of bone marrow transplantation retinopathy in a patient in the absence of prior radiation therapy.
Methods:
Case report.
Results:
Bilateral scotomata developed in a 26-year-old woman because of a retinal microvasculopathy two years after receiving an autologous bone marrow transplantation for acute promyelocytic leukemia. No prior radiation therapy had been given.
Conclusions:
Certain combinations of antimetabolites used during induction and transplantation may themselves be toxic to the retinal microvasculature. Patients who undergo bone marrow transplantation would benefit from regular and complete eye examinations, even in the absence of prior radiation therapy.