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Transient ischemia cannot precondition the rabbit heart against postischemic contractile dysfunction

G K Asimakis1, S D Lick, V R Conti

  • 1Department of Surgery, University of Texas Medical Branch, Galveston. GAsimakis@mspo2.med.utmb.edu

The Annals of Thoracic Surgery
|August 1, 1996
PubMed
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Multiple transient ischemia periods do not precondition rabbit hearts against dysfunction. The rabbit heart may lack the capacity for ischemic preconditioning, unlike rat hearts.

Area of Science:

  • Cardiovascular Physiology
  • Ischemic Preconditioning Research

Background:

  • Rat hearts exhibit preconditioning against postischemic dysfunction via transient ischemia.
  • Rabbit hearts do not show cardio-protection after a single transient ischemic period.

Purpose of the Study:

  • To investigate if multiple cycles of transient ischemia are required to precondition rabbit hearts.
  • To determine the threshold for ischemic preconditioning in rabbit hearts.

Main Methods:

  • Isolated rabbit hearts were subjected to one or three 5-minute transient ischemic periods.
  • Hearts underwent a 40-minute warm ischemia and 30-minute reperfusion period.
  • Left ventricular developed pressure was measured to assess contractile function.

Main Results:

Related Experiment Videos

  • Hearts preconditioned with one or three ischemic periods showed no significant improvement in postischemic recovery compared to controls.
  • Postischemic recovery of left ventricular developed pressure was not significantly different across groups.

Conclusions:

  • Neither one nor three transient ischemic periods protect the rabbit heart from postischemic contractile dysfunction.
  • The rabbit heart may not possess the ability to undergo ischemic preconditioning.