Effects of right ventricular failure on renal function during pneumatic left ventricular assist
Related Experiment Video
Updated: Nov 5, 2026

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS
Published on: November 26, 2018
H Akamatsu1, H Arai, T Sakamoto
1Department of Cardiothoracic Surgery, Tokyo Medical and Dental University, School of Medicine, Japan
Abstract:
In an experiment dog model of acute biventricular failure, the effects of left ventricular (LV) assist on renal hemodynamics and function were evaluated. After the induction of severe cardiac failure by multiple ligation of the coronary arteries, LV assist with a 40 ml pneumatic pulsatile pump was initiated, and the aortic flow was maintained at control values. The right atrial pressure (RAP) rose to 21.3 mm Hg with the appearance of profound right ventricular (RV) failure. Renal arterial blood flow (RAF) decreased to about 60% of the control value after 2 h of LV assist. The urine volume decreased and renal function deteriorated progressively. RV assist decreased the RAP to 4.8 mm Hg, and the reduced RAF recovered. After 3 h of RV assist, the RAF returned to initial values and the urine volume increased, but renal function did not recover. Advanced biventricular failure with elevated RAP during LV assist reduced renal perfusion and impaired renal function and may be an indication for early RV assist.
Related Concept Videos
Heart Failure II: Pathophysiology
Heart Failure III: Clinical Manifestations
Mitral Regurgitation I: Introduction
Mitral Stenosis I: Introduction
Heart Failure Drugs: Diuretics
Heart Failure VI: Adjunct Therapies
