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Updated: Aug 1, 2026

An Ex Vivo Tissue Culture Model of Cartilage Remodeling in Bovine Knee Explants
Published on: November 3, 2019
Bone chondroadherin promotes attachment of osteoblastic cells to solid-state substrates and shows affinity to
M Mizuno1, R Fujisawa, Y Kuboki
1Department of Biochemistry, School of Dentistry Hokkaido University, Sapporo Japan 060.
Abstract:
Chondroadherin, which is reported to be synthesized by chondrocytes and to promote their attachment, was purified from bovine bone. It was a minor component of bone organic matrix, and was present in the 4 M guanidine extract of demineralized bone. Chondroadherin promoted attachment of osteoblastic cells to solid-state substrates, and bound to collagen. Binding of chondroadherin to collagen was significantly higher than that of osteonectin or decorin. These findings imply that chondroadherin may play a role in maintaining bone cells on the collagen matrices of bone.
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