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Updated: Aug 9, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Multilobated B cell lymphoma (Pinkus variant) with isolated muscular localization in a patient with systemic
1Servizio Autonomo di Ematologia Diagnostica, Istituto di Scienze Mediche dell' Università degli Studi, Ospedale Maggiore IRCCS, Milan, Italy.
Abstract:
The association of systemic sclerosis (SSc) and non-Hodgkin's lymphoma (NHL) is a rare event whose pathogenesis remains to be clarified. We describe a case of NHL in a patient with SSc, in whom the NHL was particular in terms of clinical presentation (primitive muscle and bone involvement) and histologic type (large multilobated B-cell variant). The lymphoma was clinically aggressive but responded well to therapy. Surveillance for the development of "atypical" NHL is suggested in SSc cases.

