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Pentosan polysulfate-induced thrombocytopenia: a case diagnosed with an ELISA test used for heparin-induced
A Gironell1, A Altés, A Arboix
1Department of Neurology, Hospital de Sant Pau, Barcelona, Spain.
Annals of Hematology
|July 1, 1996
Abstract:
We report a patient who developed severe thrombocytopenia and ischemic stroke following pentosan polysulfate treatment. An ELISA test employed in type-II heparin-induced thrombocytopenia was highly positive. To our knowledge, this is the first case in which this test has been performed in a pentosan polysulfate-induced thrombocytopenia (PIT). Our data suggest that the antibody against pentosan polysulfate-platelet complex also cross-reacts with heparin-platelet factor 4 complex. Due to its greater sensitivity and wider availability, this ELISA test should be used in cases where PIT is suspected.