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Cardiac function in primary hyperparathyroidism before and after operation. An echocardiographic study

K Dalberg1, L A Brodin, A Juhlin-Dannfelt

  • 1Department of Surgery, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.

The European Journal of Surgery = Acta Chirurgica
|March 1, 1996
PubMed
Summary

Primary hyperparathyroidism is linked to early left ventricular dysfunction, indicated by impaired diastolic filling. Echocardiography reveals these changes, which may explain increased cardiovascular risks in affected patients.

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Operation for primary hyperparathyroidism: the new versus the old order. A randomised controlled trial of preoperative localisation.

Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society·2007

Area of Science:

  • Cardiology
  • Endocrinology
  • Medical Research

Background:

  • Primary hyperparathyroidism is associated with increased cardiovascular morbidity and mortality.
  • The underlying mechanisms for these cardiovascular complications remain incompletely understood.

Purpose of the Study:

  • To investigate potential causes of elevated cardiovascular risk in patients with primary hyperparathyroidism.
  • To assess cardiac function using echocardiography in these patients.

Main Methods:

  • A prospective, blind study was conducted at a university hospital.
  • 44 patients with primary hyperparathyroidism and 23 controls underwent echocardiography before and one year after parathyroid surgery.
  • Blood pressure and echocardiographic parameters, including mitral flow velocity (E:A ratio), were analyzed.

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Main Results:

  • Preoperatively, hyperparathyroid patients exhibited higher blood pressure and left atrial diameter compared to controls.
  • A significantly lower E:A ratio was observed in hyperparathyroid patients, indicating impaired left ventricular diastolic filling.
  • Cardiac calcifications were present in both groups, with no significant improvement in cardiac function one year post-surgery, except for reduced systolic blood pressure.

Conclusions:

  • Echocardiographic findings suggest early left ventricular dysfunction in primary hyperparathyroidism.
  • These diastolic dysfunction abnormalities may contribute to the clinical cardiovascular complications observed in these patients.